Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells

Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits termed connexins (Cxs) and are permeable to ions and small molecules. In most organs, GJCs communicate the cytoplasm of adjacent cells, while HCs communicate the intra and extracellular compartments. In this way, bo...

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Main Authors: Figueroa, Vania A., Retamal, Mauricio A., Cea, Luis A., Salas, José D., Vargas, Aníbal A., Verdugo, Christian A., Jara, Oscar, Martínez, Agustín D., Sáez, Juan C.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2014
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154469/
https://ncbi.nlm.nih.gov/pubmed/25237294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00265
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