Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells

Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits termed connexins (Cxs) and are permeable to ions and small molecules. In most organs, GJCs communicate the cytoplasm of adjacent cells, while HCs communicate the intra and extracellular compartments. In this way, bo...

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Главные авторы: Figueroa, Vania A., Retamal, Mauricio A., Cea, Luis A., Salas, José D., Vargas, Aníbal A., Verdugo, Christian A., Jara, Oscar, Martínez, Agustín D., Sáez, Juan C.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2014
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154469/
https://ncbi.nlm.nih.gov/pubmed/25237294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00265
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