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TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases

Proinflammatory cytokine TWEAK has now emerged as a key mediator of skeletal muscle-wasting in many catabolic conditions. However, the mechanisms by which TWEAK induces muscle proteolysis remain poorly understood. Here, we have investigated the role of ubiquitin-proteasome system, autophagy, and cas...

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Detalhes bibliográficos
Main Authors: Bhatnagar, Shephali, Mittal, Ashwani, Gupta, Sanjay K., Kumar, Ashok
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154369/
https://ncbi.nlm.nih.gov/pubmed/21567392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22821
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