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Antagonism of the prostaglandin E(2) EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor

The actions of prostaglandin E(2) (PGE(2)) in the kidney are mediated by G protein-coupled E-prostanoid (EP) receptors, which affect renal growth and function. This report examines the role of EP receptors in mediating the effects of PGE(2) on Madin-Darby canine kidney (MDCK) cell growth. The result...

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Hlavní autoři: Taub, Mary, Parker, Robert, Mathivanan, Paremala, Ariff, Muhamad Asnawi Mohd, Rudra, Trina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154115/
https://ncbi.nlm.nih.gov/pubmed/25007872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00510.2013
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