Teprotumumab, an IGF-1R Blocking Monoclonal Antibody Inhibits TSH and IGF-1 Action in Fibrocytes

CONTEXT: Thyroid-associated ophthalmopathy (TAO) is the component of Graves' disease characterized by orbital inflammation and connective tissue remodeling. The IGF-1 receptor (IGF-1R) and TSH receptor (TSHR) form a physical and functional complex in orbital fibroblasts. A subset of these fibro...

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Autori principali: Chen, Hong, Mester, Tünde, Raychaudhuri, Nupur, Kauh, Courtney Y., Gupta, Shivani, Smith, Terry J., Douglas, Raymond S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2014
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Hot Topics in Translational Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154099/
https://ncbi.nlm.nih.gov/pubmed/24878056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1580
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