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Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: effects of aging and family genetic background

Marked sequence variation in the mtDNA control region has been observed in human single CD34(+) cells, which persist in vivo and are present also in differentiated hematopoietic cells. In this study, we analyzed 5071 single CD34(+) cells from 49 individuals (including 31 maternally related members f...

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Autors principals: Yao, Yong-Gang, Kajigaya, Sachiko, Feng, Xingmin, Samsel, Leigh, McCoy, J. Philip, Torelli, Giuseppe, Young, Neal S.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154056/
https://ncbi.nlm.nih.gov/pubmed/23455392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2013.01.006
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