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Improved Utilization of ADAS-Cog Assessment Data Through Item Response Theory Based Pharmacometric Modeling
PURPOSE: This work investigates improved utilization of ADAS-cog data (the primary outcome in Alzheimer’s disease (AD) trials of mild and moderate AD) by combining pharmacometric modeling and item response theory (IRT). METHODS: A baseline IRT model characterizing the ADAS-cog was built based on dat...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Springer US
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4153970/ https://ncbi.nlm.nih.gov/pubmed/24595495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1315-5 |
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