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Probing the Activity Modification Space of the Cysteine Peptidase Cathepsin K with Novel Allosteric Modifiers

Targeting allosteric sites is gaining increasing recognition as a strategy for modulating the activity of enzymes, especially in drug design. Here we investigate the mechanisms of allosteric regulation of cathepsin K as a representative of cysteine cathepsins and a promising drug target for the trea...

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Detalhes bibliográficos
Main Authors: Novinec, Marko, Lenarčič, Brigita, Baici, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153677/
https://ncbi.nlm.nih.gov/pubmed/25184245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106642
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