Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes

BACKGROUND: Blood-vessel dysfunction arises before overt hyperglycemia in type-2 diabetes (T2DM). We hypothesised that a metabolomic approach might identify metabolites/pathways perturbed in this pre-hyperglycemic phase. To test this hypothesis and for specific metabolite hypothesis generation, seru...

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Detalhes bibliográficos
Main Authors: Anderson, Simon G., Dunn, Warwick B., Banerjee, Moulinath, Brown, Marie, Broadhurst, David I., Goodacre, Royston, Cooper, Garth J. S., Kell, Douglas B., Cruickshank, J. Kennedy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153569/
https://ncbi.nlm.nih.gov/pubmed/25184286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103217
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