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Transcription Blockage by Bulky End-Termini at Single-Strand Breaks in the DNA Template: Differential Effects of 5′ and 3′ Adducts

RNA polymerases from phage-infected bacteria and mammalian cells have been shown to bypass single-strand breaks (SSBs) with a single nucleotide gap in the template DNA strand during transcription elongation; however, the SSB bypass efficiency varies significantly depending upon the backbone end-chem...

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Bibliografiske detaljer
Main Authors: Neil, Alexander J., Belotserkovskii, Boris P., Hanawalt, Philip C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153415/
https://ncbi.nlm.nih.gov/pubmed/23066636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301240y
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