Hormone Resistance in Two MCF-7 Breast Cancer Cell Lines is Associated with Reduced mTOR Signaling, Decreased Glycolysis, and Increased Sensitivity to Cytotoxic Drugs

The mTOR pathway is a key regulator of multiple cellular signaling pathways and is a potential target for therapy. We have previously developed two hormone-resistant sub-lines of the MCF-7 human breast cancer line, designated TamC3 and TamR3, which were characterized by reduced mTOR signaling, reduc...

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Détails bibliographiques
Auteurs principaux: Leung, Euphemia Yee, Kim, Ji Eun, Askarian-Amiri, Marjan, Joseph, Wayne R., McKeage, Mark J., Baguley, Bruce C.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2014
Sujets:
Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153047/
https://ncbi.nlm.nih.gov/pubmed/25232533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00221
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