Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is fine-tuned and controlled by adenosine acting...

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Detalhes bibliográficos
Main Authors: Vieira, Cátia, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Silva, Isabel, Dias, Ana Sofia, Pelletier, Julie, Sévigny, Jean, Correia-de-Sá, Paulo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152956/
https://ncbi.nlm.nih.gov/pubmed/25210228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/254640
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