Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming

Maintaining the self-renewal of embryonic stem cells (ESCs) could be achieved by activating the extrinsic signaling, i.e., the use of leukemia inhibitory factor (LIF), or blocking the intrinsic differentiation pathways, i.e., the use of GSK3 and MEK inhibitors (2i). Here we found that even in medium...

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Detalhes bibliográficos
Main Authors: Chen, Guofang, Xu, Xinxiu, Zhang, Lihong, Fu, Yanbin, Wang, Min, Gu, Haifeng, Xie, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152737/
https://ncbi.nlm.nih.gov/pubmed/25145356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.112
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