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The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain

We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch c...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nozinovic, Senada, Reining, Anke, Kim, Yong-Boum, Noeske, Jonas, Schlepckow, Kai, Wöhnert, Jens, Schwalbe, Harald
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152369/
https://ncbi.nlm.nih.gov/pubmed/24921630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.29439
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