TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury

The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel expressed in pulmonary tissues, is a crucial...

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Main Authors: Balakrishna, Shrilatha, Song, Weifeng, Achanta, Satyanarayana, Doran, Stephen F., Liu, Boyi, Kaelberer, Melanie M., Yu, Zhihong, Sui, Aiwei, Cheung, Mui, Leishman, Emma, Eidam, Hilary S., Ye, Guosen, Willette, Robert N., Thorneloe, Kevin S., Bradshaw, Heather B., Matalon, Sadis, Jordt, Sven-Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152165/
https://ncbi.nlm.nih.gov/pubmed/24838754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00065.2014
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