Nonoxidative Fungicidal Mechanisms of Mammalian Granulocytes: Demonstration of Components with Candidacidal Activity in Human, Rabbit, and Guinea Pig Leukocytes

Granulocytes from the peripheral blood of normal subjects and a patient with hereditary myeloperoxidase deficiency were homogenized in 0.34 M sucrose. A granule-rich fraction, prepared by sedimentation at 27,000 × g for 20 min, contained components that killed C. parapsilosis in vitro. These were ex...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Lehrer, Robert I., Ladra, Kathryn M., Hake, Randall B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1975
Assuntos:
Pathogenic Mechanisms, Ecology, and Epidemiology
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415204/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/49298/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.11.6.1226-1234.1975
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