Nonoxidative Fungicidal Mechanisms of Mammalian Granulocytes: Demonstration of Components with Candidacidal Activity in Human, Rabbit, and Guinea Pig Leukocytes

Granulocytes from the peripheral blood of normal subjects and a patient with hereditary myeloperoxidase deficiency were homogenized in 0.34 M sucrose. A granule-rich fraction, prepared by sedimentation at 27,000 × g for 20 min, contained components that killed C. parapsilosis in vitro. These were ex...

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Autors principals: Lehrer, Robert I., Ladra, Kathryn M., Hake, Randall B.
Format: Artigo
Idioma:Inglês
Publicat: 1975
Matèries:
Pathogenic Mechanisms, Ecology, and Epidemiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC415204/
https://ncbi.nlm.nih.gov/pubmed/49298
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