Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition

Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypo...

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Autors principals: KOGITA, AKIHIRO, TOGASHI, YOSUKE, HAYASHI, HIDETOSHI, SOGABE, SHUNSUKE, TERASHIMA, MASATO, DE VELASCO, MARCO A., SAKAI, KAZUKO, FUJITA, YOSHIHIKO, TOMIDA, SHUTA, TAKEYAMA, YOSHIFUMI, OKUNO, KIYOTAKA, NAKAGAWA, KAZUHIKO, NISHIO, KAZUTO
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151805/
https://ncbi.nlm.nih.gov/pubmed/25096400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2574
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