Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing

Somatic mutations in KRAS, NRAS, and BRAF genes are related to resistance to anti-EGFR antibodies in colorectal cancer. We have established an extended RAS and BRAF mutation assay using a next-generation sequencer to analyze these mutations. Multiplexed deep sequencing was performed to detect somati...

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Udgivet i:PLoS One
Main Authors: Sakai, Kazuko, Tsurutani, Junji, Yamanaka, Takeharu, Yoneshige, Azusa, Ito, Akihiko, Togashi, Yosuke, De Velasco, Marco A., Terashima, Masato, Fujita, Yoshihiko, Tomida, Shuta, Tamura, Takao, Nakagawa, Kazuhiko, Nishio, Kazuto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425536/
https://ncbi.nlm.nih.gov/pubmed/25954997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121891
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