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DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris

Nervous system injury or disease leads to activation of glia, which govern postinjury responses in the nervous system. Axonal injury in Drosophila results in transcriptional up-regulation of the glial engulfment receptor Draper; there is extension of glial membranes to the injury site (termed activa...

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Hlavní autoři: Lu, Tsai-Yi, Doherty, Johnna, Freeman, Marc R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151738/
https://ncbi.nlm.nih.gov/pubmed/25099352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403450111
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