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Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

Glial cells efficiently recognize and clear cellular debris after nervous system injury to maintain brain homeostasis, but pathways governing glial responses to neural injury remain poorly defined. We identify the Drosophila guanine-nucleotide exchange factor (GEF) complex Crk/Mbc/dCed-12, and the s...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Ziegenfuss, Jennifer S., Doherty, Johnna, Freeman, Marc R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976689/
https://ncbi.nlm.nih.gov/pubmed/22706267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3135
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