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Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity

Developing new compounds targeting virulence factors (e.g., inhibition of pilus assembly by pilicides) is a promising approach to combating bacterial infection. A high-throughput screening campaign of a library of 17,500 small molecules identified 2-amino-3-acyl-tetrahydrobenzothiophene derivatives...

詳細記述

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書誌詳細
主要な著者: Dang, Hung The, Chorell, Erik, Uvell, Hanna, Pinkner, Jerome S., Hultgren, Scott J., Almqvist, Fredrik
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151345/
https://ncbi.nlm.nih.gov/pubmed/24531242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42478b
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