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A novel AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential
The serine/threonine kinase LKB1 is a tumor suppressor whose loss is associated with increased metastatic potential. In an effort to define biochemical signatures of metastasis associated with LKB1 loss, we discovered that the EMT transcription factor Snail1 was uniquely upregulated upon LKB1-defici...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151130/ https://ncbi.nlm.nih.gov/pubmed/25042806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.06.021 |
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