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Electroporation-mediated transfer plasmids to the lung results in reduced TLR9 signaling and inflammation
Electroporation can deliver DNA efficiently and safely to tissues in live animals, including the lung where it causes little inflammation or lung injury. In contrast, cationic lipid mediated gene transfer has been shown to induce an inflammatory response caused by unmethylated plasmid CpG residues w...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150868/ https://ncbi.nlm.nih.gov/pubmed/17344904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3302936 |
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