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Interaction of artesunate with β-cyclodextrin: Characterization, thermodynamic parameters, molecular modeling, effect of PEG on complexation and antimalarial activity

Inclusion of artesunate in the cavity of β-cyclodextrin (β-CD) as well as its methyl and hydroxypropyl derivatives was investigated experimentally and by molecular modeling studies. The effect of PEG on the inclusion was also studied. A 1:1 stoichiometry was indicated by phase-solubility studies bot...

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Autors principals: Chadha, Renu, Gupta, Sushma, Shukla, Geeta, Jain, D.V.S., Pissurlenkar, Raghuvir R.S., Coutinho, Evans C.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150620/
https://ncbi.nlm.nih.gov/pubmed/25755980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.rinphs.2011.07.002
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