Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive

BACKGROUND: Tumour microenvironment (TME) of advanced colorectal cancer (CRC) suppresses dendritic cell (DC) maturation. Here, our aim was to determine how the microenvironment of early-stage tumours influences DCs. METHODS: Tumour-conditioned media (TCM) was generated by culturing explant tumour ti...

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Detalles Bibliográficos
Autores principales: O'Toole, A, Michielsen, A J, Nolan, B, Tosetto, M, Sheahan, K, Mulcahy, H E, Winter, D C, Hyland, J M, O'Connell, P R, Fennelly, D, O'Donoghue, D, O'Sullivan, J, Doherty, G A, Ryan, E J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150274/
https://ncbi.nlm.nih.gov/pubmed/25058349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.367
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