Nuclear oxidative damage correlates with poor survival in colorectal cancer

Oxidative DNA damage results from DNA adducts such as 8-oxo-7, 8 dihydro-2′-deoxyguanosine (8-oxo-dG), which is a pro-mutagenic lesion. No known association between 8-oxo-dG, disease progression and survival exists in colorectal cancer (CRC). We examined levels of 8-oxo-dG in sporadic CRC to determi...

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Detalhes bibliográficos
Main Authors: Sheridan, J, Wang, L-M, Tosetto, M, Sheahan, K, Hyland, J, Fennelly, D, O'Donoghue, D, Mulcahy, H, O'Sullivan, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634709/
https://ncbi.nlm.nih.gov/pubmed/19066606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604821
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