High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them

High-throughput screening (HTS) provides a rapid and comprehensive approach to identifying compounds that target specific biological processes as well as genes that are essential to those processes. Here we describe a HTS assay for small molecules that induce either DNA re-replication or endoredupli...

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Bibliographic Details
Main Authors: Lee, Chrissie Y., Johnson, Ronald L., Wichterman-Kouznetsova, Jennifer, Guha, Rajarshi, Ferrer, Marc, Tuzmen, Pinar, Martin, Scott E., Zhu, Wenge, DePamphilis, Melvin L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149752/
https://ncbi.nlm.nih.gov/pubmed/22503772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2012.03.031
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