The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model

BACKGROUND AND PURPOSE: Hydrogen sulfide (H(2)S) is a highly toxic gas for which no effective antidotes exist. It acts, at least in part, by binding to cytochrome c oxidase, causing cellular asphyxiation and anoxia. We investigated the effects of three different ligand forms of cobinamide, a vitamin...

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Hlavní autoři: BRENNER, M., BENAVIDES, S., MAHON, S. B., LEE, J., YOON, D., MUKAI, D., VISEROI, M., CHAN, A., JIANG, J., NARULA, N., AZER, S. M., ALEXANDER, C., BOSS, G. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149338/
https://ncbi.nlm.nih.gov/pubmed/24716792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15563650.2014.904045
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