Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice

INTRODUCTION: It has been shown that progranulin (PGRN) deficiency causes age-related neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease. Previous studies also suggested that PGRN is involved in modulating...

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Autores principales: Tanaka, Yoshinori, Chambers, James K, Matsuwaki, Takashi, Yamanouchi, Keitaro, Nishihara, Masugi
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149276/
https://ncbi.nlm.nih.gov/pubmed/25022663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0078-x
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