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Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
INTRODUCTION: It has been shown that progranulin (PGRN) deficiency causes age-related neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease. Previous studies also suggested that PGRN is involved in modulating...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149276/ https://ncbi.nlm.nih.gov/pubmed/25022663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0078-x |
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