Polarization of Prostate Cancer-associated Macrophages Is Induced by Milk Fat Globule-EGF Factor 8 (MFG-E8)-mediated Efferocytosis

Tumor cells secrete factors that modulate macrophage activation and polarization into M2 type tumor-associated macrophages, which promote tumor growth, progression, and metastasis. The mechanisms that mediate this polarization are not clear. Macrophages are phagocytic cells that participate in the c...

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Main Authors: Soki, Fabiana N., Koh, Amy J., Jones, Jacqueline D., Kim, Yeo Won, Dai, Jinlu, Keller, Evan T., Pienta, Kenneth J., Atabai, Kamran, Roca, Hernan, McCauley, Laurie K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148880/
https://ncbi.nlm.nih.gov/pubmed/25006249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571620
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