Transforming Growth Factor (TGF)-β-activated Kinase 1 (TAK1) Activation Requires Phosphorylation of Serine 412 by Protein Kinase A Catalytic Subunit α (PKACα) and X-linked Protein Kinase (PRKX)

TGF-β-activated kinase 1 (TAK1) is a key kinase in mediating Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) signaling. Although TAK1 activation involves the phosphorylation of Thr-184 and Thr-187 residues at the activation loop, the molecular mechanism underlying the complete activati...

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Detalhes bibliográficos
Main Authors: Ouyang, Chuan, Nie, Li, Gu, Meidi, Wu, Ailing, Han, Xu, Wang, Xiaojian, Shao, Jianzhong, Xia, Zongping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148853/
https://ncbi.nlm.nih.gov/pubmed/25028512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559963
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