Islet Preparation Purity Is Overestimated, and Less Pure Fractions Have Lower Post-Culture Viability Before Clinical Allotransplantation

BACKGROUND: Replacement of β-cells with the use of isolated islet allotransplantation (IT) is an emerging therapy for type 1 diabetics with hypoglycemia unawareness. The current standard protocol calls for a 36–72-hour culture period beforeIT. We examined 13 clinical islet preparations with ≥2 purit...

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Päätekijät: Kitzmann, J.P., Karatzas, T., Mueller, K.R., Avgoustiniatos, E.S., Gruessner, A.C., Balamurugan, A.N., Bellin, M.D., Hering, B.J., Papas, K.K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148821/
https://ncbi.nlm.nih.gov/pubmed/25131080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.transproceed.2014.06.011
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