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Targeting the JAK2-STAT5 pathway in CML

In this issue of Blood, Gallipoli et al show that combined targeting of BCR/ABL1 and Janus kinase 2 (JAK2) by 2 established kinase inhibitors, nilotinib (NI) and the JAK1/2 kinase inhibitor ruxolitinib (RUX), results in synergistic growth inhibition in immature CD34(+) stem and progenitor cells obta...

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Bibliografske podrobnosti
Glavni avtor: Valent, Peter
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148757/
https://ncbi.nlm.nih.gov/pubmed/25170113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-585943
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