The Kynurenine Pathway of Tryptophan Catabolism, CD4(+) T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy

Background. Human immunodeficiency virus (HIV) infection–induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. Th...

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Autori principali: Byakwaga, Helen, Boum, Yap, Huang, Yong, Muzoora, Conrad, Kembabazi, Annet, Weiser, Sheri D., Bennett, John, Cao, Huyen, Haberer, Jessica E., Deeks, Steven G., Bangsberg, David R., McCune, Joseph M., Martin, Jeffrey N., Hunt, Peter W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148610/
https://ncbi.nlm.nih.gov/pubmed/24585899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu115
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