Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption

HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. Breakdown in gut barrier integrity is linked to chronic inflammation and disease progression. However, the early effects of HIV on the gut epithelium, prior to t...

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Detaylı Bibliyografya
Asıl Yazarlar: Hirao, Lauren A., Grishina, Irina, Bourry, Olivier, Hu, William K., Somrit, Monsicha, Sankaran-Walters, Sumathi, Gaulke, Chris A., Fenton, Anne N., Li, Jay A., Crawford, Robert W., Chuang, Frank, Tarara, Ross, Marco, Maria L., Bäumler, Andreas J., Cheng, Holland, Dandekar, Satya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148401/
https://ncbi.nlm.nih.gov/pubmed/25166758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004311
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