Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption

HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. Breakdown in gut barrier integrity is linked to chronic inflammation and disease progression. However, the early effects of HIV on the gut epithelium, prior to t...

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書誌詳細
主要な著者: Hirao, Lauren A., Grishina, Irina, Bourry, Olivier, Hu, William K., Somrit, Monsicha, Sankaran-Walters, Sumathi, Gaulke, Chris A., Fenton, Anne N., Li, Jay A., Crawford, Robert W., Chuang, Frank, Tarara, Ross, Marco, Maria L., Bäumler, Andreas J., Cheng, Holland, Dandekar, Satya
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148401/
https://ncbi.nlm.nih.gov/pubmed/25166758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004311
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