Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption

HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. Breakdown in gut barrier integrity is linked to chronic inflammation and disease progression. However, the early effects of HIV on the gut epithelium, prior to t...

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Detalhes bibliográficos
Main Authors: Hirao, Lauren A., Grishina, Irina, Bourry, Olivier, Hu, William K., Somrit, Monsicha, Sankaran-Walters, Sumathi, Gaulke, Chris A., Fenton, Anne N., Li, Jay A., Crawford, Robert W., Chuang, Frank, Tarara, Ross, Marco, Maria L., Bäumler, Andreas J., Cheng, Holland, Dandekar, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148401/
https://ncbi.nlm.nih.gov/pubmed/25166758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004311
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