Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine

According to the cancer stem cell (CSC) hypothesis, the aggressive growth and early metastasis of pancreatic ductal adenocarcinoma (PDA) is due to the activity of CSCs, which are not targeted by current therapies. Otto Warburg suggested that the growth of cancer cells is driven by a high glucose met...

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Hauptverfasser: Isayev, Orkhan, Rausch, Vanessa, Bauer, Nathalie, Liu, Li, Fan, Pei, Zhang, Yiyao, Gladkich, Jury, Nwaeburu, Clifford C., Mattern, Jürgen, Mollenhauer, Martin, Rückert, Felix, Zach, Sebastian, Haberkorn, Uwe, Gross, Wolfgang, Schönsiegel, Frank, Bazhin, Alexandr V., Herr, Ingrid
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148131/
https://ncbi.nlm.nih.gov/pubmed/25015789
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