Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine

According to the cancer stem cell (CSC) hypothesis, the aggressive growth and early metastasis of pancreatic ductal adenocarcinoma (PDA) is due to the activity of CSCs, which are not targeted by current therapies. Otto Warburg suggested that the growth of cancer cells is driven by a high glucose met...

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Detalhes bibliográficos
Main Authors: Isayev, Orkhan, Rausch, Vanessa, Bauer, Nathalie, Liu, Li, Fan, Pei, Zhang, Yiyao, Gladkich, Jury, Nwaeburu, Clifford C., Mattern, Jürgen, Mollenhauer, Martin, Rückert, Felix, Zach, Sebastian, Haberkorn, Uwe, Gross, Wolfgang, Schönsiegel, Frank, Bazhin, Alexandr V., Herr, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148131/
https://ncbi.nlm.nih.gov/pubmed/25015789
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