H-Ras regulation of TRAIL death receptor mediated apoptosis

TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis through the death receptors (DRs) 4 and/or 5 expressed on the cell surface. Multiple clinical trials are underway to evaluate the antitumor activity of recombinant human TRAIL and agonistic antibodies to DR4 or DR5. However, their thera...

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Bibliografiske detaljer
Main Authors: Chen, Jun-Jie, Bozza, William P., Di, Xu, Zhang, Yaqin, Hallett, William, Zhang, Baolin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148127/
https://ncbi.nlm.nih.gov/pubmed/25026275
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