Functional Characterization of Polymorphisms in the Peptidase Inhibitor 3 (Elafin) Gene and Validation of Their Contribution to Risk of Acute Respiratory Distress Syndrome

Elafin (peptidase inhibitor 3 [PI3]) and its biologically active precursor, pre-elafin, are neutrophil serine proteinase inhibitors with an important role in preventing excessive tissue injury during inflammatory events. Recently, we reported an association between single-nucleotide polymorphism (SN...

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Detalhes bibliográficos
Main Authors: Tejera, Paula, O’Mahony, D. Shane, Owen, Caroline A., Wei, Yongyue, Wang, Zhaoxi, Gupta, Kushagra, Su, Li, Villar, Jesus, Wurfel, Mark, Christiani, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148037/
https://ncbi.nlm.nih.gov/pubmed/24617927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0238OC
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