Differences in Fat and Muscle Mass Associated With a Functional Human Polymorphism in a Post-Transcriptional BMP2 Gene Regulatory Element

A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 inhibits myogenesis. Thus, BMP2 synthesis is tightly controlled. Several hundred...

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Main Authors: Devaney, Joseph M., Tosi, Laura L., Fritz, David T., Gordish-Dressman, Heather A., Jiang, Shan, Orkunoglu-Suer, Funda E., Gordon, Andrew H., Harmon, Brennan T., Thompson, Paul D., Clarkson, Priscilla M., Angelopoulos, Theodore J., Gordon, Paul M., Moyna, Niall M., Pescatello, Linda S., Visich, Paul S., Zoeller, Robert F., Brandoli, Cinzia, Hoffman, Eric P., Rogers, Melissa B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147943/
https://ncbi.nlm.nih.gov/pubmed/19492344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22209
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