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Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs
A disrupted balance of reduced glutathione (GSH) and iron (Fe) and subsequent enhanced susceptibility of lysosomes of lung macrophages (LMs) to oxidants may play a role in lung fibrogenesis. We assessed cellular Fe/GSH, lysosomal membrane permeabilization (LMP), and cell death in cultures of oxidant...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Libertas Academica
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4147753/ https://ncbi.nlm.nih.gov/pubmed/25278780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/JCD.S13271 |
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