Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage

BACKGROUND: Lung allografts contain large amounts of iron (Fe), which inside lung macrophages may promote oxidative lysosomal membrane permeabilization (LMP), cell death and inflammation. The macrolide antibiotic azithromycin (AZM) accumulates 1000-fold inside the acidic lysosomes and may interfere...

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Main Authors: Persson, H L, Vainikka, Linda K, Sege, Maria, Wennerström, Urban, Dam-Larsen, Sören, Persson, Jenny
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511206/
https://ncbi.nlm.nih.gov/pubmed/23006592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-83
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