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Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage
BACKGROUND: Lung allografts contain large amounts of iron (Fe), which inside lung macrophages may promote oxidative lysosomal membrane permeabilization (LMP), cell death and inflammation. The macrolide antibiotic azithromycin (AZM) accumulates 1000-fold inside the acidic lysosomes and may interfere...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3511206/ https://ncbi.nlm.nih.gov/pubmed/23006592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-83 |
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