Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Induced Prostate Carcinogenesis in CYP1A-humanized Mice

To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice. In comparison to mouse Cyp1a2, human CYP1A2 preferentially activates PhIP to a proximate carcinogen. Follo...

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Main Authors: Li, Guangxun, Wang, Hong, Liu, Anna B., Cheung, Connie, Reuhl, Kenneth R., Bosland, Maarten C., Yang, Chung S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147397/
https://ncbi.nlm.nih.gov/pubmed/22581815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-12-0023
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