Insulin Preconditioning Elevates p-Akt and Cardiac Contractility after Reperfusion in the Isolated Ischemic Rat Heart

Insulin induces cardioprotection partly via an antiapoptotic effect. However, the optimal timing of insulin administration for the best quality cardioprotection remains unclear. We tested the hypothesis that insulin administered prior to ischemia provides better cardioprotection than insulin adminis...

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Hauptverfasser: Sato, Tamaki, Sato, Hiroaki, Oguchi, Takeshi, Fukushima, Hisashi, Carvalho, George, Lattermann, Ralph, Matsukawa, Takashi, Schricker, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147204/
https://ncbi.nlm.nih.gov/pubmed/25197648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/536510
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