Effects of Replacement of Factor VIII Amino Acids Asp519 and Glu665 with Val on Plasma Survival and Efficacy In Vivo

Proteolytic cleavage of factor VIII (FVIII) to activated FVIIIa is required for participation in the coagulation cascade. The A2 domain is no longer covalently bound in the resulting activated heterotrimer and is highly unstable. Aspartic acid (D) 519 and glutamic acid (E) 665 at the A1–A2 and A2–A3...

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Main Authors: Kosloski, Matthew P., Shetty, Krithika A., Wakabayashi, Hironao, Fay, Philip J., Balu-Iyer, Sathy V.
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147049/
https://ncbi.nlm.nih.gov/pubmed/24934295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9627-2
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