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An Electrically Tight In Vitro Blood–Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

Efflux transporters of the ATP-binding cassette superfamily including breast cancer resistance protein (Bcrp/Abcg2), P-glycoprotein (P-gp/Abcb1) and multidrug resistance-associated proteins (Mrp’s/Abcc’s) are expressed in the blood–brain barrier (BBB). The aim of this study was to investigate if a b...

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Detalhes bibliográficos
Main Authors: Helms, Hans Christian, Hersom, Maria, Kuhlmann, Louise Borella, Badolo, Lasina, Nielsen, Carsten Uhd, Brodin, Birger
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147044/
https://ncbi.nlm.nih.gov/pubmed/24934296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9628-1
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