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Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/Astrocyte Blood–Brain Barrier Model by Increasing Media Buffer Capacity During Growth

Most attempts to develop in vitro models of the blood–brain barrier (BBB) have resulted in models with low transendothelial electrical resistances (TEER), as compared to the native endothelium. The aim of the present study was to investigate the impact of culture pH and buffer concentration on parac...

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Detalhes bibliográficos
Main Authors: Helms, Hans Christian, Waagepetersen, Helle Sønderby, Nielsen, Carsten Uhd, Brodin, Birger
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976989/
https://ncbi.nlm.nih.gov/pubmed/20967520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-010-9237-6
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