A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer

Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) therapeutic for treatment of human epidermal growth factor receptor 2 (HER2)-positive cancers. The T-DM1 dose product contains a mixture of drug-to-antibody ratio (DAR) moieties whereby the small molecule DM1 is chemically conjugated...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Bender, Brendan, Leipold, Douglas D., Xu, Keyang, Shen, Ben-Quan, Tibbitts, Jay, Friberg, Lena E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer US 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147041/
https://ncbi.nlm.nih.gov/pubmed/24917179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9618-3
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